It depends on whether the angle formed between them is acute or obtuse and signs of the coefficients
Let lines be
ax + by + c = 0 and a'x + b'y + c' = 0
Firstly, write ax + by + c = 0 and a'x + b'y + c' = 0 such that constant terms are positive.
If aa' + bb' > 0, then the equation of the acute angle bisector is with + sign and obtuse is with - sign
If aa' + bb' < 0, then the equation of the acute angle bisector is with - sign and obtuse is with + sign