Blood group A has antigen A and antibody anti B. Blood group O has no antigen. If blood group A is given to a person having blood group O, antibodies (anti A) develop in the person and hence, clumping occurs. But, if O is given to a person having blood group A, the transfusion is successful as O has no antigen. But, O should develop anti A antibody againt antigen A in the reciepent's blood. Yet, clumping does not occur. Why is it so?
Thanx in advance...
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2 Answers
61A person with O blood group can develop antibodies when he is transfused with A blood group. Antibodies can develop only in the blood when it is inside a person. If O group blood is donated to a person with A blood group, the O group blood is not in the donor's body any more. So who will produce the antibodies? The body of the recipient cannot, because he already has the A antigen...he won't produce antibodies against his own antigen.
51For a blood donor and recipient to be ABO-compatible for a transfusion, the recipient cannot be able to produce anti-A or anti-B antibodies that correspond to the A or B antigens on the red blood cells (since the red blood cells are isolated fro the whole blood before transfusion, it is unimportant whether the donor's blood has antibodies in its plasma). If the antibodies of the recipient's blood and the antigens on the donor's red blood cells do correspond the donor's blood is rejected. In addition to the ABO-system, the Rh-blood group system can affect transfusion compatibility. An individual is either positive or negative for the Rh-factor; tat is denoted by a'+' or '-' after their ABO type. Blood that is Rh-negative can be transfused to Rh-positive, but an Rh-negative individual can create antibodies for Rh-positive RBCs. Because of this AB+ blood is referred to as 'universal recipient', as it possesses neither anti-A nor anti-B antibodies in its plasma, and can receive both Rh-negative and Rh-positive blood, Similarly, the O-blood type is called 'universal donor' since its red blood cells have no A or B antigens and are Rh-negative, no other blood type will reject it.
