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dH = dU + PdV

"In the biological setting most all reactions occur in a large excess of fluid, therefore, essentially no gases are formed during the course of the reaction. This means that the value ΔV, is extremely small and thus the product PΔV is very small as well. The values ΔU and ΔH are very nearly equivalent in biological reactions."

So what can we conclude?

well since G increases ΔG>0

Hence the process must be non spontaneous. Don't know about the other options though.