is it only the +I effect of 2 methyl groups on nitrogen that makes N,N- dimethylpicramide more basic than picramide....???? Or some other effect also???
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2 Answers
11Due to steric effect -NMe2 goes out of the plane..therefore steric inhibition of resonance occurs..therefore + R effect wont occur,,therefore e- is much more available for donation..therefore making it much more basic.