Doubt.....

Regioselectivity can be achieved when unsymmetrical ketones are used in directed aldol reaction by generating the kinetic enolate using LDA. This ensures the production of enolate in which proton has been removed

1. From less substituted alpha carbon

2. From more substituted alpha carbon

3. From that carbon which forms less stable carbanion

4. From that carbon which forms more stable carbanion

1 Answers

39
Pritish Chakraborty ·

Less substituted/More acidic alpha carbon.

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